Wednesday, April 23, 2025
| 09h00 | Welcome Coffee- Registration |
| 09h45 | Introduction by organizing committee |
|
Lymphatic Development |
|
| 10h00 | Karina Yaniv | Formation and Malformations of Lymphatic Vessels
|
| 10h30 | Taija Makinen | Decoding lymphatic vessel heterogeneity and function at the single-cell level
|
| 11h00 | Stefan Schulte-Merker | New genes in old pathways: lymphatics in zebrafish, mice and men
|
| 11h30 | Short com : David Grainger |Investigating in vivo specification as a blueprint for engineering lymphatic endothelial cells |
| 11h45 | Short com : Sanjay Sunil Kumar | Carboxypeptidase D, a novel player involved in VEGFC processing and lymphatic development |
| 12h00 | Short com : Francizka Lehne | Modulation of Vegfc/Vegfr3 Signaling by Apelin drives Lymphangiogenesis in Zebrafish |
| 12h15 – 13h30 | LUNCH BREAK Salle des Colonnes Hôtel Dieu |
|
Molecular Mechanisms |
|
| 13h30 | Barbara Garmy-Susini | Novel therapeutic options for secondary lymphedema
|
| 14h00 | Kathleen Caron | Meningeal Lymphatics in Migraine Pain
|
| 14h30 | Mathias François | Gene repression at work: Trim28 a novel regulator of lymphangiogenesis
|
| 15h00 | Short com : Claudia Carlantoni |Novel phosphodiesterase 2A function in the lymphatic and blood vasculature |
| 15h15 | Short com : Hannah Arnold | Deciphering the chromatin landscape and regulatory logic behind lymphatic endothelial cell fate using a multi-omics approach |
| 15h30 | Short com : Silvia Martin Almedina | VEGFC response in immortalised lymphatic endothelial cells: a new in vitro model to interrogate Primary Lymphoedema genetic variants? |
| 15h45 | COFFEE BREAK |
|
Immune Crosstalk |
|
| 16h15 | Maria Ulvmar | Lymph Node Vasculature: Key to Immune Regulation and Disease Progression
|
| 16h45 | Antoine Louveau | Regulation of social behavior by meningeal lymphatic vasculature during neurodevelopment
|
| 17h15 | Short com : Kelly De Korodi | Aquaporin-1 sustains lymphangiogenic response in inflammatory microenvironments |
| 17h30 | Short com : Bojana Jakic | Regulation of the homeostatic maintenance of lymph node lymphatic vasculature |
| 17h45 | Short com : Sara Cascione | ETV2-mCherry/TetOn-PROX1-StayGold human induced pluripotent stem cells: a novel tool for inducing and tracking lymphatic endothelial cell differentiation in vitro |
| 18h00 | Short com : Adam Lokman | Lymphangiogenic therapy following myocardial infarction induces immune tolerance and leads to improved cardiac outcomes in mice with underlying myocarditis |
| 18h15 – 19h30 | POSTERS SESSION |
Thursday, April 24, 2025
SESSION 4 |
Interorgan Communication |
|
| 09h00 | Tatiana Petrova | Mechanisms of intestinal lymphatic specialization
|
| 09h30 | Kari Alitalo | Translational insights into lymphangiogenic growth factors
|
| 10h00 | Lenka Rossmeislova | Interplay between human adipocytes and lymphatic endothelial cells
|
| 10h30 | Short com : Karina Hadrian |Mutation in the Pax6 gene leads to an ingrowth of lymphatic vessels into the cornea and ananiridia-like phenotype |
| 10h45 | Short com : Theo Lemarcis |Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model |
| 11h00 | COFFEE BREAK |
SESSION 5 |
Lymphatics in Cancer & Metabolism
|
| 11h30 | Gilles Pages | Comparative effects of proton and photon irradiation on the molecular and cellular profiles of triple-negative breast cancer: the crucial impact of VEGFC on tumor microenvironment remodeling
|
| 12h00 | Lothar Dieterich | Lymph node lymphatic endothelial control of tumor immunity and progression
|
| 12h30 | Short com : Kerstin Wilhelm Jüngling | FOXO1-Mediated Transcrip onal Control of Lympha c Matura on and Implications for Whole-Body Metabolism |
| 12h45 | Short com : Päivi Ojala | Viral hijacking of SOX18 pioneer activity: unveiling a lymphatic transcription factor’s role in oncogenic viral infection |
| 13h00 | Short com Muyun Gong | Pathogenic loss-of-function variants of ribosomal protein RPL10a cause Milroy-like primary lymphedema |
| 13h15 – 14h15 | LUNCH BREAK Salle des Colonnes Hôtel Dieu |
| 14h15 – 15h15 | POSTERS SESSION |
| 15h00 – 17h00 | FREE TIME |
SESSION 6 |
Microenvironment | Chair : Maike Frye |
| 17h00 | Agnès Noel | Altered trafficking of VE-cadherin and lymphatic vessel architecture attenuate lymphedema
|
| 17h30 | Anne Eichmann | Leveraging lymphatics to improve health
|
| 18h00 | Mariona Graupera | Insights on PI3K mutations in lymphatic malformations
|
| 18h30 | Short com : Mickael M Orlich | Loss of myogenic activity in smooth muscle cells drives lymphatic malformations |
| 18h45 | Short com : Florent Morfoisse | Role of Lysyl Oxidase in the pathological interplay between extracellular matrix and lymphatics in secondary lymphedema |
| 19h00 | Short com : Ana Angulo | Exploring the role of PIK3CA variants in vascular malformations: A combined molecular and experimental modeling strategy
|
| 19h30 | GALA DINER HOTEL DIEU SAINT JACQUES Salle des Colonnes |
Friday, April 25, 2025
SESSION 7 |
Lymphatic Diseases |
|
| 08h30 | Stanley Rockson | Pharmacology for Lymphedema: Treating a Systemic Disease
|
| 09h00 | Miikka Vikkula | Novel insights into the pathophysiology of lymphedema
|
| 09h30 | Alessandra Bura-Riviere
|
| 10h00 | Short com : Joseph Turner | Bioactive lipid pathways are druggable therapeutic targets in experimental lymphatic filariasis pathology |
| 10h15 | Short com : Pia Ostergaard | Noncoding variants in Milroy Disease and Lymphoedema Distichiasis Syndrome |
| 10h30 | COFFEE BREAK |
SESSION 8 |
New Tools & Technologies | Chair : Ebba Brakenheim |
| 11h00 | Felipe Opazo | Strategies for imaging multiple targets using engineered Nanobodies with erasable signals
|
| 11h30 | Rene Hägerling | Spatial Deep Phenotyping of human and murine tissues using lightsheet imaging and nanobody technology
|
| 12h00 | Christine Duthoit |FlashRNA®: an innovative solution leveraging the potential of RNA for tomorrow’s therapies. Now available for Theralymph
|
| 12h15 | Short com : Zoltàn Jakus | Characterization of the role of lymphatics in organ-specific responses induced by nucleoside-modified mRNA-based platforms |
| 12h30 | END OF THE MEETING |
Sponsors
